Cannabinoids — the active components of
Using nude mice, Casanova et al. injected the mixed CB1/CB2 agonist WIN-55,212-2 or the selective CB2 agonist JWH-133 into the epidermis adjacent to induced non-melanomic malignancies and observed a considerable inhibition in tumor growth. Cannabinoid-treated tumors showed an increased number of apoptotic cells, altered blood vessel morphology and decreased expression of proangiogenic factors (VEGF, placental growth factor, and angiopoietin 2). In addition, abrogation of EGF-R function was also observed in cannabinoid-treated tumors.
"The present report, ...