For this article, Leslie Pray interviewed William C. Hahn, postdoctoral fellow at the Whitehead Institute for Biomedical Research in Cambridge, Mass., and an oncologist at the Dana-Farber Cancer Institute in Boston. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.

W.C. Hahn, C.M. Counter, A.S. Lundberg, R.L. Beijersbergen, M.W. Brooks, R.A. Weinberg, "Creation of human tumour cells with defined genetic elements," Nature, 400:464-8, July 29, 1999. (Cited in 177 papers)

Courtesy of Justin Knight

William C. Hahn

For nearly two decades, scientists have been generating cancer cells in the lab using specific combinations of oncogenes. But, up until two years ago, they could only do this with rodent cells. Generating human tumor cells required other methods, such as irradiation and chemical treatment. However, these methods produced mutations...

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