David Botstein

First Person | David Botstein Courtesy of Frank Wojciechowski At the age of 60, David Botstein, microarray and genetics pioneer, is learning to play the cello. As a young man, Botstein seriously considered being a musician, but he knew the talent just wasn't there. "I did play the violin, badly," he admits. Yet his love of music is so ingrained--his brother, Leon, is music director for the American Symphony Orchestra--that even as an undergraduate at Harvard, he "ran with the musicians."

| 4 min read

Register for free to listen to this article
Listen with Speechify
0:00
4:00
Share

At the age of 60, David Botstein, microarray and genetics pioneer, is learning to play the cello. As a young man, Botstein seriously considered being a musician, but he knew the talent just wasn't there. "I did play the violin, badly," he admits. Yet his love of music is so ingrained--his brother, Leon, is music director for the American Symphony Orchestra--that even as an undergraduate at Harvard, he "ran with the musicians."

Botstein, who recently became head of Princeton's Lewis-Sigler Institute for Integrative Genomics, did not come to genetics easily. First it was engineering, then physics, then biochemistry. He found religion, so to speak, after reading the Molecular Basis of Evolution by nobelist Christian B. Anfinsen.

Botstein has no regrets. "I thought about [music] very seriously. It was pretty clear to me, being reasonable and objective about it, that I didn't have what it takes. There's nothing worse than going ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here
February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Sino Biological Logo

Sino Biological Pioneers Life Sciences Innovation with High-Quality Bioreagents on Inside Business Today with Bill and Guiliana Rancic

Sino Biological Logo

Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

Beckman Coulter

Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

Refeyn logo

Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies