Dealing in Relationships

Joseph Schlessinger would hardly fit most people's definition of the unworldly scientist. Originally a physicist, Schlessinger has conducted groundbreaking work in identifying and characterizing molecules in the signaling pathways of receptor tyrosine kinases. Elected to the National Academy of Sciences in 2000, Schlessinger, William H. Prusoff professor and chairman of pharmacology at Yale University, has achieved the acclaim some scientists yearn for. Yet in 1991, when he set out to build a c

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Perhaps everyone should be so green. With help from his partners, Axel Ullrich, an important early scientist in Genentech, the San Francisco-based biotechnology firm, and Stephen Evans-Freke, a former investment banker turned biotechnology entrepreneur, Schlessinger built SUGEN Inc. In 1999, the colossal pharmaceutical company Pharmacia Corp. acquired SUGEN for $720 million, even before it had marketed its first drug. Schlessinger went on to help found a second company, Plexxikon, based on the structural genomics discoveries of cofounder Sung-Yo Kim at the University of California, Berkeley, but he has learned some lessons on the way. "In order to prevent the mistakes I made in the past, I created checks and balances," Schlessinger says.

Creating such safegaurds begins with negotiations for the final deal--when the scientist-inventor tries to sketch terms that supply abundant cash for development and provide the inventor reasonable profits. Many fledgling inventors end up like Schlessinger--dissatisfied with the corporate ...

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