Epigenetic epidemiology is rising in popularity, but the field presents technical challenges not found in genetic epidemiology. DNA methylation is often cell type-specific, making it difficult to epigenotype an individual using peripheral blood DNA. However, correlated regions of systemic inter-individual epigenetic variation (CoRSIV) target-capture bisulfite sequencing allows researchers to use easily biopsied tissues such as peripheral blood to study systemic epigenetic differences among individuals and identify disease-associated epigenetic variation.
Download this application note from Agilent Technologies to learn more about how researchers use CoRSIV panels to assay SIVs in large population studies and discover associations with human diseases.
