The central nervous system (CNS) is exquisitely tuned for performing its many core functions, but disease and dysfunction can impede its work. Disease biomarkers are chemical signatures of pathologic processes, detection of which enables diagnosis and progression analysis from blood, cerebrospinal fluid, or tissue biopsy. Biomarkers of CNS disorders have been successfully exploited for their diagnostic and prognostic value, becoming ever more valuable in the fight against insidious diseases that invade and damage our most essential organ system.

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