The Scientist, among many other sources, appears unaware of the original discovery of gasotransmission.1 Almost 10 years before Solomon Snyder's group demonstrated that nitric oxide (NO) was involved in gaseous neurotransmission, researchers in South Africa provided evidence for a role for nitrous oxide (N2O).2 This work was confirmed by workers in 1989.3

This major achievement for a Third World country deserves wider recognition.

Mark A. GillmanSA Brain Research Institute Waverley, South Africa

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