DNA Hard Drive

Researchers design the first rewritable biological data storage system.

Written byMegan Scudellari
| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

NATIONAL HUMAN GENOME RESEARCH INSTITUTE

Researchers at Stanford University in California have programmed DNA to function as a rewritable biological data storage system. The research was published Monday (May 21) in the Proceedings of the National Academy of Sciences.

"One of the coolest places for computing is within biological systems," senior author Drew Endy told the BBC. His team spent three years designing the system, which consists of two enzymes that splice DNA sequences from a bacteriophage—a bacteria-infecting virus—into the E. coli genome. Once inserted, the DNA sequence points in one of two directions, like a '0' or a '1' in binary. Based on its orientation, the inserted gene expresss either a green or red fluorescent protein, causing the cell to glow green or red.

Past DNA-based storage systems, which ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina
Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

Abstract illustration of spheres with multiple layers, representing endoderm, ectoderm, and mesoderm derived organoids

Organoid Origins and How to Grow Them

Thermo Fisher Logo

Products

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo
Abstract background with red and blue laser lights

VANTAstar Flexible microplate reader with simplified workflows

BMG LABTECH