Don't Be Phased by Phenol Extractions: PLG from 5 Prime -> 3 Prime Offers Worry Free Extractions

Pour off the aqueous phase when you use Phase Lock Get. Look Ma, No Pipette! Pulling an aqueous phase off an organic phase is a truly hateful and hated task. Many an hour has been spent by many a researcher doing just that. With each extraction, a decision must be made-whether to go for purity, which often can only be achieved by leaving some aqueous behind, or for recovery by taking all you can, including some of the protein you're trying to get rid of. 5 Prime -> 3 Prime has come out with

| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

Pour off the aqueous phase when you use Phase Lock Get. Look Ma, No Pipette! Pulling an aqueous phase off an organic phase is a truly hateful and hated task. Many an hour has been spent by many a researcher doing just that. With each extraction, a decision must be made-whether to go for purity, which often can only be achieved by leaving some aqueous behind, or for recovery by taking all you can, including some of the protein you're trying to get rid of. 5 Prime -> 3 Prime has come out with a product that will put all these worries behind you. The Phase Lock Gel (PLG) is a proprietary compound that creates a barrier between the aqueous and organic phases of an extraction, essentially trapping the organic phase below the PLG. You don't even need to use a pipette. The barrier is so durable that you can ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here
Image of a man in a laboratory looking frustrated with his failed experiment.
February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Sino Biological Logo

Sino Biological Pioneers Life Sciences Innovation with High-Quality Bioreagents on Inside Business Today with Bill and Guiliana Rancic

Sino Biological Logo

Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

Beckman Coulter

Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

Refeyn logo

Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies