Edited by: Paul Smaglik
G.G.J.M. Kuiper, B. Carlsson, K. Grandien, E. Enmark, J. Haggblad, S. Nilsson, J.A. Gustafsson, "Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and ß ," Endocrinology, 138:863-70, March 1997. (Cited in more than 265 papers since publication)

Comments by Jan-Åke Gustafsson, professor and chairman, Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden, and chairman, Department of Biosciences at Novum, Huddinge University Hospital, Huddinge, Sweden

Before April 1996, researchers studying estrogen binding only saw half the picture. Then Jan-Åke Gustafsson reported a novel estrogen receptor (ER), ER ß , and he and colleagues formally published their results.1 This 1997 follow-up paper compared ligand-binding specificities of the classical ER-alpha and the novel ERß. "The homology in the ligand-binding domain between the two receptors was about 58 percent, so both differences and similarities were to be expected," he comments....

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