Engineered Monkeys Could Aid Autism Research

Monkeys genetically engineered with multiple copies of an autism-linked human gene display some autism-like behaviors, scientists show.

Written byCatherine Offord
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Crab-eating macaque monkey (M. fascicularis)WIKIMEDIA, CHRIS HUH

The MECP2 gene, which codes for a protein involved in transcriptional regulation and microRNA processing, is frequently duplicated in the genomes of people showing symptoms of autism. Now, a team of researchers in China has reported that monkeys genetically engineered to contain multiple copies of MECP2 also show some autism-like behaviors, supporting claims that monkeys would be good models to study the condition. The team’s findings were published earlier this week (January 25) in Nature.

The monkeys display “very similar behaviors related to human autism patients, including repetitive behaviors, increased anxiety and, most importantly, defects in social interactions,” study coauthor Zilong Qiu of the Institute of Neuroscience at the Chinese Academy of Sciences in Shanghai told The New York Times.

The researchers injected virus-transported human ...

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Meet the Author

  • After undergraduate research with spiders at the University of Oxford and graduate research with ants at Princeton University, Catherine left arthropods and academia to become a science journalist. She has worked in various guises at The Scientist since 2016. As Senior Editor, she wrote articles for the online and print publications, and edited the magazine’s Notebook, Careers, and Bio Business sections. She reports on subjects ranging from cellular and molecular biology to research misconduct and science policy. Find more of her work at her website.

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