A CRISPR-Cas9 enzyme (orange) cutting a DNA strand (blue)
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.
ABOVE: © iStock.com, Design Cells
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels

A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.

A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.

ABOVE: © iStock.com, Design Cells
genetic engineering
Histological stain of motor neurons in purple and green
Researchers Use Ultrasound to Control Neurons in Mice
Natalia Mesa | Feb 9, 2022
A study shows “sonogenetics” could be a useful new tool in neuroscience and other fields.
Abstract geometric heart with plexus effect on blue background
Man Receives Transplanted Heart from Genetically Modified Pig
Shawna Williams | Jan 10, 2022
The procedure, performed last Friday, is a milestone in a long effort to boost the number of organs available for safe transplantation.
Molecular Farming: The Future of Pharmaceuticals
The Scientist Speaks - Molecular Farming: The Future of Pharmaceuticals
Niki Spahich, PhD | Nov 16, 2021
Julian Ma discusses past, present, and future uses of plant biotechnology for disease treatments.
rice plants growing in a room with metal walls under artificial light
Rice-based Cholera Vaccine Induces Antibodies in Small Trial
Alejandra Manjarrez | Jul 8, 2021
Immune-response levels to the edible vaccine varied among the subjects, possibly due to differences in the gut microbiome.
FDA Clears Genetic Modification in Pigs for Biomedicine and Food
Catherine Offord | Dec 15, 2020
The decision, which concerns the removal of a sugar molecule on the surface of cells in a line of domestic pigs, marks the first time an approval has been granted for both purposes simultaneously.
Repurposing a Pathogenic Bacteria’s Weapon
LabTalk Podcast - Bugs with Drugs: Repurposing a Pathogenic Bacteria’s Weapon
The Scientist Creative Services Team | Apr 16, 2021
Cammie Lesser describes her research developing designer probiotics to deliver protein-based therapeutics to the gut.
Researchers Who Discovered Hepatitis C Earn Nobel Prize
Max Kozlov | Oct 5, 2020
Harvey Alter, Michael Houghton, and Charles Rice share the Physiology or Medicine award for their contributions to identifying the virus and demonstrating that it was responsible for hepatitis among blood transfusion recipients.
750 Million GM Mosquitoes Will Be Released in the Florida Keys
Lisa Winter | Aug 21, 2020
There have been no reports of health or environmental harm in other locations where genetically modified mosquitoes have been introduced over the last decade.
Humans Inoculated with Genetically Modified Malaria Parasites
Ruth Williams | May 20, 2020
Engineered Plasmodium parasites form the basis of two experimental malaria vaccines that showed safety and encouraging immune responses in clinical trials.
Infographic: Building Bacteria to Fight Cancer
Simone Schuerle, Tal Danino | Apr 1, 2020
Researchers are engineering microbes to deliver therapeutics specifically to tumors, maximizing the treatments’ efficacy while minimizing side effects.
Bacteria as Living Microrobots to Fight Cancer
Simone Schuerle, Tal Danino | Apr 1, 2020
Autonomous, living microrobots that seek and destroy cancer are not as futuristic as one might imagine, thanks to a fusion of robotics and synthetic biology.
Engineered Microbe in Bees’ Guts Fends off Deadly Varroa Mite
Lisa Winter | Jan 31, 2020
The genetically modified bacteria spark an RNAi response in the parasite that leads to self-destruction—and perhaps a path to combatting colony collapse disorder.
mosquito aedes aegypti jacobina brazil oxitec genetic engineering gm genetically modified dengue zika
GM Mosquito Progeny Not Dying in Brazil: Study
Kerry Grens | Sep 17, 2019
The biotech Oxitec had released the genetically engineered insects with the hope that they would breed with wild populations and produce offspring that die young. But that’s not always happening.
Timing and Order of Molecular Events Recorded in Live Cells’ DNA
Ruth Williams | Aug 22, 2019
Genetic engineers have co-opted base editing machinery to enable information storage and processing in the DNA of bacterial and mammalian cells.
FDA Lifts Import Restrictions on Genetically Engineered Salmon
Catherine Offord | Mar 11, 2019
The fast-growing fish can now be raised and sold in the US, although it’s likely to be some time before the product hits the market.
Gene Drive–Equipped Mosquitoes Released into Lab Environment
Jef Akst | Feb 20, 2019
The large-scale experiments aim to test how the technology would fare in the wild, if deployed to knock down populations of the pests.
MO
Better Base Editing in Plants
Ruth Williams | Feb 1, 2019
Adenine editing enzymes have been adapted for use in plants.
MO infographic
Infographic: Plant Genome Editors Get A New Tool
Ruth Williams | Feb 1, 2019
Adenine editing enzymes have been adapted for use in plants.
Opinion: GE Crops Are Seen Through a Warped Lens
Rod A. Herman, Nicholas P. Storer, Bryan Delaney | Feb 1, 2019
Risks that pertain to all manner of new crops are often misattributed to genetic engineering. This distorts the public’s view of the technology.