Every cell within the human body contains the same DNA, but not all cells look and act alike. The key to cellular diversity lies in which genes the cells express or shut down. Cells convey this information to the appropriate machinery through epigenetic modifications. In this episode, Charlene Lancaster from The Scientist spoke with Jonathan Weissman from the Massachusetts Institute of Technology and Luke Gilbert from the University of California, San Francisco to learn about making epigenetic changes in vitro and the application of these tools in research and the clinic.

More on this topic: CRISPR Gene Editing: Cas9 and Beyond

The Scientist Speaks is a podcast produced by The Scientist’s Creative Services team. Our podcast is by scientists and for scientists. Once a month, we bring you the stories behind news-worthy molecular biology research. This month's episode is sponsored by Cytosurge, Molecular Devices, and Eppendorf.


Jonathan Weissman

Jonathan Weissman, PhD
Professor, Biology
Massachusetts Institute of Technology
Landon T. Clay Professor of Biology and Core Member, Whitehead Institute
Investigator, Howard Hughes Medical Institute

Luke Gilbert

Luke Gilbert, PhD
Associate Professor, Urology
Goldberg-Benioff Endowed Professor in Prostate Cancer Translational Biology
University of California, San Francisco

Cytosurge is proud to offer the FluidFM Biopsy Solution for live-cell sequencing through single-cell biopsies, where researchers extract cytoplasmic material from a cell without compromising its viability. Because single-cell biopsies provide a snapshot representation of a living cell’s transcriptome at a given point in time, the FluidFM Biopsy Solution enables the correlation between the transcriptome and the cell’s phenotype without removing it from its culture environment. Learn more at www.cytosurge.com/r/Uav.

Molecular Devices is one of the world’s leading providers of high-performance bioanalytical measurement systems, software, and consumables for life science research, and pharmaceutical and biotherapeutic development. Included within a broad product portfolio are platforms for high-throughput screening, genomic and cellular analysis, colony selection and microplate detection. These leading-edge products enable scientists to improve productivity and effectiveness, ultimately accelerating research and the discovery of new therapeutics. For more information, please visit www.moleculardevices.com.

Eppendorf is a leading life science company that develops and sells instruments, consumables, and services for liquid, sample, and cell handling. Their product range includes pipettes and automated pipetting systems, centrifuges, mixers, spectrometers, thermal cyclers, ultra-low temperature freezers, fermenters, bioreactors, CO2 incubators, shakers, cell manipulation systems, and all accompanying consumables. Learn more at https://eppendorf.group/zxtrum.

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