Each issue, The Scientist publishes a review of some related papers highlighted by the Faculty of 1000, plus comments on new and notable research. For more information visit www.facultyof1000.com.
Recent work on rats from Vadim Arshavsky, associate professor of ophthalmology, Harvard University, and his colleagues have revealed that under certain conditions, signaling proteins translocate en masse out of the rod's outer segment, where light is captured.1 Work from Armin Huber, group leader in the Department of Cell and Neurobiology at the University of Karlsruhe, Germany, shows a similar translocation event among ion channel proteins in fly rhabdomeres.2 Recently reviewed by the Faculty of 1000, these papers, says Roger Hardie, senior member of the Department of Anatomy, Cambridge University, provides well-defined model systems to dissect the cellular and molecular mechanisms involved in massive intracellular translocation of signaling proteins.
Nearly 15 years ago, researchers first observed light-induced translocation of signaling proteins between ...
