H.J. Pel et al., "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88," Nat Biotechnol, 25:221-31, 2007. (Cited in 65 papers)
Hein Stam and colleagues at DSM Food Sciences in The Netherlands sequenced the genome of Aspergillus niger CBS 513.88, a fungus used to commercially produce a wide variety of enzymes and organic acids. The team assembled a detailed metabolic network consisting of more than 1,000 unique biochemical reactions, and predicted the functions of more than 6,000 putative genes.
Sequencing A. niger's genome "opened up a black box," says Pacific Northwest National Laboratory's Scott Baker, who was not an author on the Hot Paper. He adds that the work identifies genes and gene products, such as transcription factors, regulatory factors, and secondary metabolites that affect the production of commercial enzymes used in everything from bread and beer making to paper production.
Study first author Herman Pel ...
