H. Kiyokawa, R.D. Kineman, K.O. Manova-Todorova, V.C. Soares, E.S. Hoffman, M. Ono, D. Khanam, A.C. Hayday, L.A. Frohman, and A. Koff. "Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1," Cell, 85:721-32, 1996. (Cited in more than 155 papers since publication)
Comments by Andrew Koff, associate member of the molecular biology program, Memorial Sloan-Kettering Cancer Center, New York
Cyclin-dependent kinase (CDK) inhibitors act as a traffic cop of cell division. However, the precise signals these proteins issue to direct cells have eluded researchers.
Andrew Koff and colleagues proposed three potential ways these proteins might stop and start cellular proliferation:
"The question that then comes up is, 'How do you identify a cell type which is displaying any one of those functions for any one of the different CDK inhibitors?'" Koff notes.
A definitive answer remained elusive, since seven known CDK inhibitors had been identified and tagged with ...
