Genomics 101

Undergraduate students delve into genomics and synthetic biology thanks to a new breed of technologically advanced courses.

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ANDRZEJ KRAUZE

James DiCarlo was only a freshman at Johns Hopkins University in the spring of 2007 when his research advisor, Jef Boeke, approached him about taking a new class Boeke was putting together.

“Do you think students would be interested in a class about synthetic biology and building genomes?” DiCarlo recalls Boeke asking.

“I was like, ‘Yeah, that sounds awesome, I would take that class,’” DiCarlo, now a grad student in biomedical engineering at Boston University, recalls.

That class was Biology 420, aka Build-a-Genome. Instead of concentrating on typical cookbook-style experiments, Build-a-Genome teaches undergrads the fine points of synthetic biology and then turns them loose to rebuild their own 10-kilobase slice of yeast chromosome three. The course, a kind of lab class–cum-independent project, was conceived as ...

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