“Silent” Mutation Linked to Worse Kidney Cancer Outcome
“Silent” Mutation Linked to Worse Kidney Cancer Outcome
A synonymous mutation in the tumor suppressor gene BAP1 can result in loss of function of the protein without altering its amino acid sequence.
“Silent” Mutation Linked to Worse Kidney Cancer Outcome
“Silent” Mutation Linked to Worse Kidney Cancer Outcome

A synonymous mutation in the tumor suppressor gene BAP1 can result in loss of function of the protein without altering its amino acid sequence.

A synonymous mutation in the tumor suppressor gene BAP1 can result in loss of function of the protein without altering its amino acid sequence.

genetics & genomics
Another Potentially Immunity-Evading SARS-CoV-2 Variant Detected
Another Potentially Immunity-Evading SARS-CoV-2 Variant Detected
Asher Jones | Feb 16, 2021
B.1.525 shares a mutation with the B.1.351 variant first detected in South Africa that seems to allow the virus to dodge the immune system.
SARS-CoV-2 with Genomic Deletions Escapes an Antibody
SARS-CoV-2 with Genomic Deletions Escapes an Antibody
Abby Olena | Feb 16, 2021
Researchers identify deletions in the N-terminal domain of the spike protein that allow the coronavirus to avoid antibody neutralization and that may contribute to the emergence of new variants.
Gene-Edited Organoids Explore Neanderthal Brain Function
Gene-Edited Organoids Explore Neanderthal Brain Function
Jef Akst | Feb 12, 2021
Using CRISPR to swap an archaic variant of the NOVA1 gene into human stem cells, researchers create organoids with neurodevelopmental differences from those carrying modern DNA.
Polycystic Ovary Syndrome May Be Inherited Epigenetically
Polycystic Ovary Syndrome May Be Inherited Epigenetically
Katarina Zimmer | Feb 9, 2021
Female mice modeling the hormonal disorder can pass symptoms down for several generations, likely via changes in genome methylation that are similarly observed in women with PCOS.
Human Cells Can Synthesize DNA in Their Cytoplasm
Human Cells Can Synthesize DNA in Their Cytoplasm
Alejandra Manjarrez | Feb 8, 2021
While studying a degenerative eye disease, researchers find the first evidence that cells produce endogenous DNA in the cytoplasm. Drugs that block this activity are linked with reduced risk of atrophic age-related macular degeneration.
Vaccines Versus the Mutants
Vaccines Versus the Mutants
Anthony King | Feb 8, 2021
Facing new variants of SARS-CoV-2, some vaccines may offer more robust protection or be more easily redesigned to target them.
A Simple Genetic Change Adds Limb-Like Bones to Zebrafish Fins
A Simple Genetic Change Adds Limb-Like Bones to Zebrafish Fins
Abby Olena | Feb 5, 2021
A gain-of-function mutation in a single gene reveals ancient limb-forming capacity that has been preserved for hundreds of millions of years.
Will Delaying Vaccine Doses Cause a Coronavirus Escape Mutant?
Will Delaying Vaccine Doses Cause a Coronavirus Escape Mutant?
Chris Baraniuk | Feb 4, 2021
With many millions of people waiting several weeks to receive a second COVID-19 vaccine dose in some countries, experts consider the possibility that SARS-CoV-2 could evolve vaccine resistance.
Respected Medical Geneticist Sir Peter Harper Dies at 81
Respected Medical Geneticist Sir Peter Harper Dies at 81
Catherine Offord | Feb 2, 2021
The Cardiff University researcher was famous both for his work on genetic disorders and for his documentation of the history of his field.