Genetic Risks for Depression Differ Between Ancestral Groups
Genetic Risks for Depression Differ Between Ancestral Groups
A large genome-wide association study in East Asians uncovers novel genetic links to depression, calling attention to the consequences of underrepresentation of non-European groups in genetic research data.
Genetic Risks for Depression Differ Between Ancestral Groups
Genetic Risks for Depression Differ Between Ancestral Groups

A large genome-wide association study in East Asians uncovers novel genetic links to depression, calling attention to the consequences of underrepresentation of non-European groups in genetic research data.

A large genome-wide association study in East Asians uncovers novel genetic links to depression, calling attention to the consequences of underrepresentation of non-European groups in genetic research data.

genetics & genomics
Alzheimer’s Risk Gene Paradoxically Protects Against Memory Loss
Alzheimer’s Risk Gene Paradoxically Protects Against Memory Loss
Chloe Tenn | Oct 8, 2021
A new study links a variant of the apolipoprotein E gene called APOE ε4 to better memory in older age, even in the presence of amyloid plaques—a possible explanation for the variant’s persistence despite its association with an increased risk of Alzheimer’s disease.
Contributors
Contributors
The Scientist Staff | Oct 1, 2021
Meet some of the people featured in the October 2021 issue of The Scientist.
Identical Twins Carry Distinctive Epigenetic Marks: Study
Identical Twins Carry Distinctive Epigenetic Marks: Study
Chloe Tenn | Sep 30, 2021
Researchers found more than 800 sites in the genome where the twins bore the same chemical tags.
Infographic: A Yeast Model for Studying Histone Modifications
Infographic: A Yeast Model for Studying Histone Modifications
Amanda Heidt | Sep 1, 2021
The methodology involves modifying histones and displaying them on the cell surface for analysis.
Yeast “Mini Labs” Help Researchers Probe Histone Modifications
Yeast “Mini Labs” Help Researchers Probe Histone Modifications
Amanda Heidt | Sep 1, 2021
By harnessing a unique property of yeast, scientists can synthesize histones and the enzymes that modify these proteins, which spool DNA and influence gene expression.
Mechanosensory Protein Helps Tendons Stiffen After Exercise
Mechanosensory Protein Helps Tendons Stiffen After Exercise
Catherine Offord | Sep 1, 2021
Researchers identify a role for PIEZO1 in tendon adaptation, and show that people with certain versions of the Piezo1 gene tend to be better jumpers.
Fish Species’ Y Chromosomes Diverged Even Without Recombination
Fish Species’ Y Chromosomes Diverged Even Without Recombination
Catherine Offord | Sep 1, 2021
Researchers discover surprisingly high levels of genetic diversity among the colorful male morphs of a freshwater fish.
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Abby Olena | Aug 18, 2021
RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.
Indigenous Filipino Group Has Highest Known Denisovan Ancestry
Indigenous Filipino Group Has Highest Known Denisovan Ancestry
Annie Melchor | Aug 13, 2021
Researchers found the relatively high proportion of DNA from a hominin cousin—nearly 5 percent—when they scanned more than 1,000 genomes from 118 distinct ethnic groups.
Participant’s Diagnosis Halts Gene Therapy Clinical Trial
Participant’s Diagnosis Halts Gene Therapy Clinical Trial
Amanda Heidt | Aug 12, 2021
The FDA pauses the research program on a lentivirus-based treatment for a rare neurological condition after a patient developed a bone marrow disorder that could presage leukemia.
Freeze-Dried Mouse Sperm Sent by Postcard Produces Baby Mice
Freeze-Dried Mouse Sperm Sent by Postcard Produces Baby Mice
Amanda Heidt | Aug 5, 2021
Rather than relying on samples that need to be shipped in glass vials and on ice, researchers have developed a new method that allows mouse sperm to be sent easily at room temperature using standard mail delivery.
Exercising During Pregnancy Protects Mouse Offspring
Exercising During Pregnancy Protects Mouse Offspring
Jack J. Lee | Aug 1, 2021
Obese mice that exercised while pregnant gave birth to pups that grew up free of the metabolic issues present in the adult young of sedentary obese mothers—possibly by staving off epigenetic changes to a key metabolic gene.
Gene Offers Clue to How Human Labor Starts
Gene Offers Clue to How Human Labor Starts
Christie Wilcox | Aug 1, 2021
Genes associated with preterm birth and protecting the fetus from the mother’s immune system appear to be regulated by HAND2.