Citizen Scientists Help Geneticists and Microbiologists Tackle Large-Scale Challenges

From playing video games to exploring the depths of the Pacific, biology enthusiasts help researchers collect and analyze data like never before.

Written byThe Scientist Staff
| 3 min read
An arcade within the Borderlands video game, next to a hazard sign.
Register for free to listen to this article
Listen with Speechify
0:00
3:00
Share

With limited time and limited budgets, how can scientists hope to gather samples from many species or from far-flung locations to build a more complete picture of the natural world? Increasingly, researchers are enlisting the help of enthusiastic non-experts to help with these projects. Computational biologists ask gamers to help them discern evolutionary relationships between different types of gut bacteria, entomologists enlist students to identify insect species that carry an important endosymbiont, and microbiologists team up with bakers to catalog the diverse spectrum of microbes that are responsible for the complex flavors of sourdough bread.

Borderlands Gamers Fuel the Next Generation of Citizen Science

To figure out how groups of organisms are related to one another, researchers run comparisons across multiple DNA sequences. While computers are an integral part of this process, the trickier parts still require a human touch. “The truth is that there's no real rule for doing this,” said Jérôme Waldispühl, a computational biologist at McGill University. “Often, it's about looking at the pattern, the context in which a mutation or an insertion or deletion occurs. It’s relying on the aesthetic of the alignment…We needed to figure out how to integrate the human mind into the computing process at scale.” Waldispühl and his collaborators designed an arcade-style game, almost like Tetris, and placed it inside the Borderlands 3 videogame, enabling unprecedented citizen science participation in determining relationships between microbes in the human gut.

Continue reading below...

Like this story? Sign up for FREE Newsletter updates:

Latest science news storiesTopic-tailored resources and eventsCustomized newsletter content
Subscribe

Continue reading to get the full story.

In Search of Microbes That Weave Colors into Moroccan Carpets

Image of synthetic and cotton dyed with purple-producing microbes.

Brooke Jude searches for novel pigment-producing microbes and has used naturally purple-pigmented microbes to dye synthetic and cotton fabrics.

Anne Madden, The Microbe Institute

Bacteria can produce a spectrum of colors, from muted tones to dazzling hues. For molecular microbiologist Brooke Jude of Bard College, there was an abundance of purple pigment-producing microbes in the Hudson River Valley watershed around her. The purple pigment, violacein, is known for its antimicrobial properties which help amphibians fight off chytridiomycosis, a fungal disease. To explore their potential and striking coloration, she enlisted citizen scientists to help identify and catalog more of these purple-hued microbes.

Discover more about these vibrant purple microbes in this story.

A Microbial Ally to Bring Science to the Masses

While the bacterium Wolbachia pipientis was discovered more than 100 years ago, there’s still a lot that researchers don’t know about this important insect endosymbiont. Now, an organization called The Wolbachia Project is leveraging this interesting microbe to help students in middle school, high school, and college engage with the scientific process and learn about DNA extraction, amplification, and sequencing as they attempt to identify new arthropod species that carry this microbe.

Keep reading to learn more about this science engagement project.

DNA Metabarcoding Reveals Hidden Biodiversity

The citizen science project Sequencing The Rivers for Environmental Assessment and Monitoring (STREAM), led by Mehrdad Hajibabaei, a molecular biologist at the University of Guelph, enlists community members to help researchers study the health of streams and rivers across Canada. By analyzing sediment samples that have been sent to them, researchers use DNA metabarcoding to identify which species of invertebrates and algae are present. This helps researchers assess how environmental changes, like climate change, pollution, or restoration efforts affect biodiversity and ecosystem health.

Explore the DNA of Canada’s rivers in in this digest article.

A person works with their sourdough starter in the kitchen.

Donated sourdough starters helped researchers uncover the factors that influence microbial communities in these living cultures.

Erin Lemieux

Bakers Rise Up to Tackle Sourdough Mysteries

Bread is a staple on many dinner tables, and sourdough’s tangy flavor has captivated bakers for generations. Yet, the mystery of the microbes that give it its distinct taste still puzzles many. This curiosity led Rob Dunn, an ecologist and evolutionary biologist at North Carolina State University, to launch the citizen science project The Science of Sourdough in 2016. Over 500 people worldwide donated their sourdough starters, allowing researchers to explore how location affects microbial species, while also examining factors like aroma, flour type, rise time, and height.

Dig into these tasty insights in this article.

Fishermen and Hobbyists Provide Scientists with Invaluable Data

Some small fishing boats on the Pacific Ocean have been keeping detailed records of their catch for years. Now, Stanford marine biologists like William Gilly are taking advantage of this data, combined with climate information, to help figure out the underlying factors contributing to changes in the populations of fish and squid in this region. Gilly was able to link El Niño events, which make deep ocean waters much warmer than usual, with phenotypic changes in the squid, explaining the disappearance of large squid from this region in recent years.

There’s more fish in the sea. Check out this story to keep reading.

You might also be interested in...
Loading Next Article...
You might also be interested in...
Loading Next Article...
Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

View this Issue
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Pacific Biosciences logo
Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad
Conceptual image of a doctor holding a brain puzzle, representing Alzheimer's disease diagnosis.

Simplifying Early Alzheimer’s Disease Diagnosis with Blood Testing

fujirebio logo

Products

Labvantage Logo

LabVantage Solutions Awarded $22.3 Million U.S Customs and Border Protection Contract to Deliver Next-Generation Forensic LIMS

The Scientist Placeholder Image

Evosep Unveils Open Innovation Initiative to Expand Standardization in Proteomics

OGT logo

OGT expands MRD detection capabilities with new SureSeq Myeloid MRD Plus NGS Panel