Ten months after Microsoft founder Bill Gates announced his "Grand Challenges in Global Health" research initiative in Davos, Switzerland, a hand-picked panel of international scientists has drafted a list of 14 challenges, whose solutions could lead to important healthcare advances for the developing world. The list appears in today's issue of the journal Science.

The 14 challenges include controlling infectious disease through new and improved vaccines and better management and eradication of the insects that transmit agents of disease. Others call for improved nutrition and better disease measurement in both individuals and populations. Each challenge will receive grants of up to $20 million over 5 years or less. The Bill and Melinda Gates Foundation is funding this $200 million project, which is administered by the Foundation for the National Institutes of Health.

A description of deliberations that led to selection of the 14 global health challenges and an outline...

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