Chromosomes are composed of functionally distinct domains separated by chromatin boundaries. In the August 10 Science, Noma et al. define the boundaries of the heterochromatin domain at the mating-type locus (mat) in fission yeast (Science 2001, 293:1150-1155).They used chromatin immunoprecipitation (ChIP) and PCR analysis to scan the entire mat region (about 47 kilobases). Methylation of lysine 9 of histone H3 and the Swi6 protein were both enriched in a 20kb interval that contains the mat2/3 s
Chromosomes are composed of functionally distinct domains separated by chromatin boundaries. In the August 10
They used chromatin immunoprecipitation (ChIP) and PCR analysis to scan the entire
In contrast, methylation of lysine 4 of histone H3 showed an inverse pattern and was excluded from the mat
Thus, distinct H3 methylation patterns define euchromatic (H3-Lys4-Methyl) ...
A long-term study of nearly 800 patients demonstrated a strong safety profile for T cells engineered with viral vectors.
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