M.H. Siegelman, M. van de Rijn, I.L. Weissman, "Mouse lymph node homing receptors cDNA clone encodes a glycoprotein revealing tandem interaction domains," Science, 243, 1165-72, 3 March 1989.
Mark Siegelman (Stanford University Medical Center, Calif.): "Our characterization of the lymph node-specific homing receptor protein showed it to be composed of a core protein with complex and novel posttrans- lational modifications. Our cloning of the cDNA encoding the core polypeptide revealed an entirely new class of adhesion molecule with a remarkable protein design. This design consists of a tandem array of three independent protein domains brought together to form the homing receptor protein. These domains are a lectin domain, an epidermal growth factor-like domain, and two similar repeats of a motif present in a number of proteins that regulate the complement cascade. The unique juxtaposition of these protein segments recruited into a single molecule provides a rich model for study of ...
