"Therefore, this paper provides a link between incoming signals from extracellular stimuli and the activation of a network of genes (including fos and jun) whose gene products are able to transactivate secondary genes in response to the stimulus."
"The article considers, among other matters, the findings that many eukaryotic regulatory proteins work when bound to sites a great distance removed from the controlled gene; that at least one class of activators discovered in yeast will activate genes in many-perhaps all-eukaryotes; and that very often different regulators work together (cooperatively) to control gene expression.
"The ideas discussed describe these phenomena in terms of (or in contrast with) the workings of the lambda phage repressor, the case for which we have our most detailed molecular understanding. It will be interesting to see in what ways the picture offered is an oversimplification."
