How single cell proteomics data can drive CAR-Treg-based therapies—an interview with Leonardo Ferreira

Leonardo Ferreira, a postdoctoral fellow at the University of California, San Francisco, discusses the application of single cell proteomics data to understanding the function and therapeutic potential of genetically engineered regulatory T cells.

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Given the roles of CD4+ and CD8+ T cells as searchers and destroyers, it is no surprise that much of the chimeric antigen receptor (CAR)-T cell development centers on “conventional” T cells. In contrast, regulatory T cells (Tregs) reside more in the background. However, as stewards of immune homeostasis, their role is no less important.

Interest in genetically engineered Tregs, including CAR-Tregs, for therapeutic use is growing. Leonardo Ferreira is a postdoctoral fellow at the University of California, San Francisco, where he studies the effects of cell therapies on the immune system. We spoke to him about his work with CAR-Tregs.

The functional differences between CAR-Tregs and "conventional" CAR-T cells

While conventional CAR-T cell therapies are designed to kill specific cells, CAR-Tregs are designed to prevent cell killing. “Most T cells are dedicated to defending our body from pathogenic invaders and cancer. They recognize peptides derived from viruses, bacteria, or ...

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