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How Tumors Tire Out T Cells

Researchers investigated how cancer antigenicity drives unique forms of T cell exhaustion and hypofunctionality.

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It remains unclear why some tumor types do not respond to immune checkpoint blockade (ICB) therapies. Researchers at KU Leuven investigated CD8⁺ T cell functionality across different tumor types to determine what drives the hypofunctional T cell state in ICB-nonresponsive cancers. They used single-cell proteomics to uncover the mechanisms behind CD8⁺ T cell dysfunction in glioblastoma.

Download this research summary from Bruker Cellular Analysis to learn how researchers used the IsoCode® Single-Cell Secretome platform to define new immune cell populations in low antigenic tumors and pave the way for new immunotherapies.

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