Image: Courtesy of Atto Bioscience
 SHARPER IMAGE: A section of mouse intestine imaged with both confocal and non-confocal microscopy

Confocal imaging systems offer a number of improvements over conventional wide-field fluorescent microscopes, including greater spatial resolution and enhanced image quality. Most commercial confocal systems employ laser scanners, but these systems are generally expensive to purchase and maintain. And, because a given laser source can be tuned to emit at only a limited number of wavelengths, multiple lasers are required for investigators needing a modicum of flexibility with regard to fluorophore choice.

As an alternative to laser-based imaging, Atto Bioscience of Rockville, Md., offers its CARV® technology, which enables full-spectrum, high-resolution confocal imaging in real time. The company currently offers this technology in two different formats: CARV modules, which scientists can use to add confocal imaging capabilities to inverted or upright epifluorescent microscopes purchased from a variety of manufacturers; and...

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