Skip to main content

Imaging in 4-D

Just a few short decades ago, cell biologists--essentially relegated to the tissue culture equivalent of Flatland--couldn't imagine working in three dimensions without sacrificing their subjects, much less having the ability to view the impact of their work in real time, over time. Now, state-of-the-art imaging technologies and new biological reagents and probes are sending biologists and other scientists on fantastic voyages into the molecular world of living animals to watch how cancer develop

Written byA. J. S. Rayl
| 10 min read

Register for free to listen to this article
Listen with Speechify
0:00
10:00

"This isn't just three-dimensional biology--this is four-dimensional analysis," enthuses molecular biologist Harvey R. Herschman, director of basic research at the Jonsson Comprehensive Cancer Center, University of California, Los Angeles. UCLA is home to one of three new In vivo Cellular and Molecular Imaging Centers, or ICMICs, established early this year with the support of grants from the National Cancer Institute (NCI). The other two centers are at Massachusetts General Hospital/Harvard Medical School in Boston and Memorial Sloan-Kettering Cancer Center in New York.

"The focus today is really on molecular--in imaging, biology, genetics, pharmacology, and medicine," says

UCLA's Michael E. Phelps, who co-developed positron emission tomography (PET) in the mid-1970s1,2 and serves as chair of the department of molecular and medical pharmacology at UCLA School of Medicine. "With the sequencing of the genomes and the proteomes taking us to a very fundamental molecular characterization of how cells function and how they ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?
Add The Scientist as a preferred source on Google

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

Published In

Related articles background image
August 2026 Digest cover
August 2026

Epic Fail: Sea-Monkeys Sabotage Fieldwork

When Barry Hicks set out to photograph thrombolites, thousands of unexpected visitors photobombed his underwater images.

View this Issue
Advancing Respiratory Immunity Through Tissue-Resident Memory T Cell Research

Advancing Respiratory Immunity Through Tissue-Resident Memory T Cell Research

Miltenyi
Overcoming Immunotherapy Resistance in Liver Cancer

Overcoming Immunotherapy Resistance in Liver Cancer

Axion Biosystems
Optimizing NGS Library Preparation for Reliable Sequencing Data

Optimizing NGS Library Preparation for Reliable Sequencing Data

Covaris
Using TCR Repertoire Sequencing to Advance Immunology Research

Using TCR Repertoire Sequencing to Advance Immunology Research

Miltenyi

Products

Sino Biological Logo

Sino Biological Launches SuperNuclease ® Pro with Free Trial Program

Sino Biological Logo

Sino Biological Launches Precisely Characterized Full-Length p-Tau217 Protein to Advance Next-Generation Alzheimer’s Biomarker Assay Development

A photo of a scientist placing the Resipher device on a 96-well plate.

Resipher: Continuous Live-Cell Mitochondrial Respiration Monitoring in 96-Well Plates

Lucid Scientific logo
Conceptual image of ice and frost.

The VAULT100 PRO: Inside the most advanced Stirling Ultracold ULT freezer ever built.

Stirling Ultracold logo