Skip to main content

Immune to Failure

With dogged persistence and an unwillingness to entertain defeat, Bruce Beutler discovered a receptor that powers the innate immune response to infections—and earned his share of a Nobel Prize.

Written byKaren Hopkin
| 9 min read

Register for free to listen to this article
Listen with Speechify
0:00
9:00

BRUCE BEUTLER
Director, Center for the Genetics of Host Defense
The University of Texas Southwestern Medical Center
© BRIAN COATS FOR UT SOUTHWESTERN MEDICAL CENTER
Bruce Beutler published his first scientific paper at the age of 16. As an apprentice in his father’s lab at the City of Hope National Medical Center in Duarte, California, Beutler learned how to purify proteins and assay their activity—work that led to a pair of publications on the enzyme glutathione peroxidase, including that first one in the Annals of Human Genetics in 1974.

“I don’t think there were any other students in my high school who were spending their afternoons and weekends that way,” laughs Beutler. “But in those days I was very ambitious.” Graduating from the University of California, San Diego, when he was 18, Beutler went on to obtain a medical degree from the University of Chicago. “That was something my father advised me to do. He said, ‘If you go to medical school, you’ll learn all about the workings of one specific organism.’” This knowledge, Ernest Beutler told his son, “will be extremely useful to you, no matter what you decide to do in biology.”

“He also said, ‘If you don’t do well, you’ll have something to fall back on. You can always see patients.’” ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?
Add The Scientist as a preferred source on Google

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

Related Topics

Published In

Related articles background image
The Scientist Digest cover September 2026
September 2026

Multiplex Microscopy Becomes Easier with Encoded Antibodies

A new system that enables researchers to uniquely tag monoclonal antibodies for use in microscopy could help simplify complex imaging studies.

View this Issue
Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Alamar Biosciences logo
Best Practices for qPCR Assay Design and Optimization

Best Practices for qPCR Assay Design and Optimization

Bio-Rad
Beyond the Basics: Strategies for Single-Cell and Spatial Transcriptomics Analysis

Beyond the Basics: Strategies for Single-Cell and Spatial Transcriptomics Analysis

bioxcell
Scientist reviewing cellular and molecular data on a computer in a laboratory.

Building Translation-Ready Biomarkers with Connected Workflows

Danaher Logo

Products

Closeup image of a multi channel pipette dispensing pink liquid into a 96-well plate.

The ASSIST PLUS pipetting robot for affordable workflow automation

Integra Logo
Single cells in suspension

Rapidly isolate primary cells and make uniform single-cell suspensions with Corning® Cell Strainers

Corning logo
Abstract image representing cell membranes linked together.

CellBrite® Steady Membrane Stain: Cell surface staining built for real-time imaging

Biotium
sino biological logo

Monod Bio Licenses AI-designed Protein Technologies to SignalChem Biotech for Custom Discovery Assays