The HIV protein Nef can cause long-term genetic changes that lead to hyperreactive immune cells, according to research in human cells and mice. 

Pregnancy-induced changes in the immune system are key to a successful birth. Understanding those changes could allow researchers to protect both mother and child.

Aberrant immune activation, the main cause of prematurity and stillbirths, could be preventable through interventions such as maternal vaccination. 

In people with the genetic condition, inflammation can cause a mild infection to snowball out of control, a study finds.

Recent studies have lent support for a variety of hypotheses explaining the debilitating symptoms affecting millions of people after SARS-CoV-2 infection.  

Genetic variants that reduce the editing levels of double-stranded RNA are associated with autoimmune and immune-mediated conditions, a study finds.

Human data and experiments in mice challenge the common use of anti-inflammatory drugs to treat pain.

Studies suggest SARS-CoV-2 infection could trigger the development of diabetes in some people, even those with no other risk factors.

Roseolovirus infection disrupts how the body trains immune cells not to attack it, a mouse study shows.

A new link between inflammation and rampant chromosomal abnormalities reveals novel strategies to treat diverse malignancies.

When micronuclei rupture, chromosomes break, recombine, and form circles, causing inflammation and promoting carcinogenic growth.

Several research groups have found that Toxoplasma gondii infection can ramp up antitumor immune responses in mice. Can the single-cell parasite be used to develop safe treatments for humans?

Researchers identify a sensor that sets off inflammation in the absence of infection when it detects RNA from the mobile genetic elements.