Holoclara

Holoclara

Holoclara is the first biotechnology company to create orally available, symbiont-derived chemistry designed to provide relief to millions of people living with allergic and autoimmune disease. Co-founded and led by physician-scientist Andrea Choe, Holoclara mines immunomodulatory molecules from gut dwelling symbionts, building upon decades of preclinical data proving their therapeutic efficacy across a wide range of diseases. With a team of world-renowned experts in worm biology, experience in developing biotechnologies, and the backing of leading life sciences and technology investors, Holoclara is uniquely positioned to harness the therapeutic potential of symbionts to address historically untreatable diseases

Content by Holoclara

Abstract image of worms, showing purple and blue curved tubes

Turning Worm-Derived Molecules into Life-Changing Therapies

July Digest 2025
July 2025, Issue 1

What Causes an Earworm?

Memory-enhancing neural networks may also drive involuntary musical loops in the brain.

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Explore synthetic DNA’s many applications in cancer research

Weaving the Fabric of Cancer Research with Synthetic DNA

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Illustrated plasmids in bright fluorescent colors

Enhancing Elution of Plasmid DNA

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An illustration of green lentiviral particles.

Maximizing Lentivirus Recovery

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Explore new strategies for improving plasmid DNA manufacturing workflows.

Overcoming Obstacles in Plasmid DNA Manufacturing

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