C.R. Taylor, S.-R. Shi, B. Chaiwun, L. Young, S.A Imam, R.J. Cote, "Strategies for improving the immunohistochemical staining of various intranuclear prognostic markers in formalin-paraffin sections-androgen receptor, estrogen receptor, progesterone receptor, p53 protein, proliferating cell nuclear antigen, and ki-67 antigen revealed by antigen retrieval techniques," Human Pathology, 25:263-70, 1994. (Cited in more than 35 publications as of April 1996)

Comments by Richard J. Cote and Clive R. Taylor, University of Southern California School of Medicine

This article describes a new technology called antigen retrieval, a technique to enhance tissue staining and "improve the reproducibility of the results of immunohistochemistry," explains Richard J. Cote, an associate professor of pathology at the University of Southern California (USC) School of Medicine.

HEAT WAVE: From left, USC's San-Rong Shi, Clive Taylor, and Richare Cote report that a new technology, antigen retrieval, has revolutionized tissue staining and immunohistochemistry.
The process entails subjecting processed...

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