Immunology

T.L. Walunas, D.J. Lenschow, C.Y. Bakker, P.S. Linsley, G.J Freeman, J.M. Green, C.B. Thompson, J.A. Bluestone, "CTLA-4 can function as a negative regulator of T-cell activation," Immunity, 1:405-13, 1994. (Cited in more than 40 publications as of February 1996) Comments by Jeffrey A. Bluestone, University of Chicago, and Craig B. Thompson, Howard Hughes Medical Institute, University of Chicago TURN-OFF:Jeffrey Bluestone hopes to understand how the immune system shuts itself down. In this

Written byJeffrey Bluestone
| 3 min read

Register for free to listen to this article
Listen with Speechify
0:00
3:00
Share

T.L. Walunas, D.J. Lenschow, C.Y. Bakker, P.S. Linsley, G.J Freeman, J.M. Green, C.B. Thompson, J.A. Bluestone, "CTLA-4 can function as a negative regulator of T-cell activation," Immunity, 1:405-13, 1994. (Cited in more than 40 publications as of February 1996)

Comments by Jeffrey A. Bluestone, University of Chicago, and Craig B. Thompson, Howard Hughes Medical Institute, University of Chicago


TURN-OFF:Jeffrey Bluestone hopes to understand how the immune system shuts itself down.
In this paper, Jeffrey Bluestone and his collaborators at the University of Chicago, along with colleagues at New York-based Bristol-Myers Squibb Co. and Harvard University, examined the role of CTLA-4, an immune system protein.

"CTLA-4 was of interest because it was a homolog-a gene with the same structure, chromosomal location, ligands-of a molecule called CD28," explains Craig B. Thompson, a professor of medicine and a Howard Hughes Medical Institute investigator at the University of Chicago.

CD28 has intrigued immunologists because ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
July Digest 2025
July 2025, Issue 1

What Causes an Earworm?

Memory-enhancing neural networks may also drive involuntary musical loops in the brain.

View this Issue
Genome Modeling and Design: From the Molecular to Genome Scale

Genome Modeling and Design: From the Molecular to Genome Scale

Twist Bio 
Screening 3D Brain Cell Cultures for Drug Discovery

Screening 3D Brain Cell Cultures for Drug Discovery

DNA and pills, conceptual illustration of the relationship between genetics and therapeutic development

Multiplexing PCR Technologies for Biopharmaceutical Research

Thermo Fisher Logo
Discover how to streamline tumor-infiltrating lymphocyte production.

Producing Tumor-infiltrating Lymphocyte Therapeutics

cytiva logo

Products

The Scientist Placeholder Image

Sino Biological Sets New Industry Standard with ProPure Endotoxin-Free Proteins made in the USA

sartorius-logo

Introducing the iQue 5 HTS Platform: Empowering Scientists  with Unbeatable Speed and Flexibility for High Throughput Screening by Cytometry

parse_logo

Vanderbilt Selects Parse Biosciences GigaLab to Generate Atlas of Early Neutralizing Antibodies to Measles, Mumps, and Rubella

shiftbioscience

Shift Bioscience proposes improved ranking system for virtual cell models to accelerate gene target discovery