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Industry Researchers Decry Tone Of NIH Gene Therapy Panel Report

In what some industry observers liken to biotechnology's early days of scientific hope mixed with public pessimism, gene therapy has come under the scope of scrutiny at the National Institutes of Health. A much-publicized December panel report commissioned by NIH director Harold Varmus lambastes companies' use of clinical trials to lure investors; urges stringent peer review of gene therapy protocols; calls for more basic research; and warns that "overselling of the industry" could cause a back

Written byKathryn Brown
| 7 min read

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Arbno Motulsky Caution: Panel cochairman Arno Motulsky says gene therapy "has great promise" but notes "many hurdles it needs to overcome."

"Much of what they said was right in the sense that there is a lot of basic research to be done, and it doesn't help to be hyping the field," says Alan Smith, senior vice president of research at Genzyme Corp., a publicly held gene therapy company in Cambridge, Mass. "On the other hand, part of running a business is getting funded, and hype wouldn't be unheard of. The biotech industry was accused of that in the beginning." "Academic and commercial-based gene therapy programs will likely have different reactions to the report," predicts James Wilson, director of the Institute for Human Gene Therapy at the University of Pennsylvania Medical Center. Wilson, who is also a founder of and consultant to Genovo Inc., a gene therapy startup based in Philadelphia, says it ...

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