Reagents for Nuclear Hormone Receptor Research
Courtesy of Karo Bio AB |
![]() Effect of an agonist (red spheres) or agonist/antagonist (green spheres) on the C terminal helix of the ligand binding domain of the estrogen receptor |
Unlike receptors found on the cell surface, members of the nuclear hormone receptor (NHR) superfamily are restricted to metazoan organisms such as nematodes, insects, and vertebrates.1 These proteins are intracellular transcription factors that directly regulate gene expression in response to lipophilic molecules. They affect a wide variety of functions, including fatty acid metabolism, reproductive development, and detoxification of foreign substances. Because of the ubiquitous and ...