May 2000

How can members of Congress find out what they're getting for all the money they appropriate for biomedical research? Ten years ago, former Democratic Maine representative Peter Kyros and his associate Belle Cummins, along with Rep. George W. Gekas (R-Pa.), came up with an inspired answer: a command performance biomedical seminar program featuring a who's who list of scientists as invited speakers. On March 29, invited speaker Harold Varmus, former director of the National Institutes of Health,

They're in your labs, classes, and journal clubs. You may advise them, or they may advise you. You may even be one of them. "They" are foreign-born life scientists, whose numbers and prominence have increased greatly over the past 20 years. But far from exulting in their undeniable achievements,1 many researchers who have come to the United States from abroad are in a state of quiet desperation. They're caught up in the increasingly clogged and dysfunctional immigration system run by the

Graphic: Cathleen Heard The pharmaceutical industry instantly took note when the federal government granted U.S. patent number 6,048,850 to the University of Rochester on April 11, 2000. The patent for "Method of inhibiting prostaglandin synthesis in a human host," described as "broad," "dominant," and "blocking" in the lexicon of the patent attorney, had a distinct everything-but-the-kitchen sink flavor about it. The patent covers inhibitors of the enzyme cyclooxygenase-2 (COX-2) that include n

Courtesy of Media Services, Yale School of Medicine Left, a stained section of spontaneous lung metastasis showing normal lung tissue adjacent to melanoma tissue. Arrows delineate melanoma composed predominantly of melanin-containing cells. Right, cultured cells from spontaneous lung metastasis. Metastasis, the spread of cancer cells from primary tumor to new sites, often prevents successful cancer treatment. But how or why certain cells detach from a tumor, travel to distant locations in the bo

Harold Varmus Harold Varmus left the directorship of the National Institutes of Health last January to head Memorial Sloan-Kettering Cancer Center in New York. But he didn't leave his strong opinions behind in Bethesda, Md. At a media forum sponsored by Syracuse University in New York on May 1, he discussed some volatile issues in biomedical research: On genome sequencing: Though the finishing line is arbitrary, "There is a point in the minds of most scientists when they say, 'OK, I think I kno

HGP Enters Final Phase: Even as the Human Genome Project (HGP) enters its final phase, which officially began May 9, perhaps the most fundamental bit of genomic trivia persists: Exactly how many human genes are there? At the 13th annual Cold Spring Harbor Meeting on Genome Sequencing and Biology held May 10, scientists marveled at the astounding acceleration of sequencing efforts in the last year. Participants, including all 16 leaders of the HGP sequencing centers, enjoyed the most recent seque

Regarding your comments on scientists renaming their rediscoveries1: While scientists may be among the most guilty, they're certainly not the only ones doing this. In fact, this rediscovery behavior is currently being encouraged throughout the entire educational system, where the latest pedagogical fashion is constructivist learning. In science education, from preschool through college, it is now considered more correct to emphasize student-led "inquiry" than factual instruction on what's "alrea

In Walter Brown's recent essay on reasons people fear genetically modified (GM) food,1 he attributed that fear to some type of "reverence for nature and natural order." Dr. Brown missed the three major players contributing to public mistrust of GM food: economics, politics, and advertisement. Much of the Europeans' fear of GM food stems from the fact that they are being told by the public media that the foods may not be safe. Reports on the potential banes greatly outnumber the reports on the be

Gregory Ogilvie works with both animal and human cancers. Not too long ago, when a dog or cat owner learned that a pet had cancer, it meant a death sentence for the animal. But things have changed. There is a "very sophisticated population of animal owners," notes Donald Thrall, professor of radiology and radiation oncology at North Carolina State University (NCSU) College of Veterinary Medicine. These people are "very informed and sometimes almost demand state-of-the-art cancer treatment" for

Common Denominator in Breast Cancer While breast cancer devastates all those affected, researchers have had a tough time finding a common denominator at the molecular level. Now Saraswati Sukumar, associate professor of oncology and pathology, and colleagues at the Johns Hopkins Oncology Center have identified a molecular alteration affecting the vast majority of primary breast cancers. Hypermethylation of the 14-3-3 s gene (s) and subsequent loss of expression are the most consistent molecular

For this article, Nadia S. Halim interviewed Christopher K. Glass, professor of cellular and molecular medicine at the University of California, San Diego. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. M. Ricote, A.C. Li, T.M. Willson, C.J. Kelly, and C.K. Glass, "The peroxisome proliferator-activated receptor-g is a negative regulator of macrophage activation," Nature, 391:79-82, Jan.

For this article, Nadia S. Halim interviewed Kenneth W. Kinzler, professor of oncology at Johns Hopkins Oncology Center. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. T.C. He, A.B. Sparks, C. Rago, H. Hermeking, L. Zawel, L.T. da Costa, P.J. Morin, B. Vogelstein, K.W. Kinzler, "Identification of c-MYC as a target of the APC pathway," Science, 281:1509-12, Sept. 4, 1998. (Cited in more t

Reagents for Nuclear Hormone Receptor Research Courtesy of Karo Bio ABEffect of an agonist (red spheres) or agonist/antagonist (green spheres) on the C terminal helix of the ligand binding domain of the estrogen receptor The survival of a living system depends on its ability to communicate with and respond to its surroundings. Even the simplest unicellular organism has surface molecules for assessing the external environment. Evolution of complex life forms required intricate methods for respo

Instrumentation for Microarray Production and Analysis - Part 1 Instrumentation for Microarray Production and Analysis - Part 2 Nanogen's NanoChip™ Cartridge Today's molecular biology era can be defined by the dictum, "So many genes, so little time," and technologies for gathering genetic information are gaining speed. DNA microarrays are one of the most promising answers to that cry. DNA microarrays are glass microslides or nylon membranes containing DNA samples (genomic DNA, cDNA,