Two immunologists, John W. Kappler and Philippa Marrack, have been awarded Columbia University's 1994 Louisa Gross Horwitz Prize for their ground-breaking work in identifying the mechanisms by which T cells, one of the immune system's central components, are able to differentiate between foreign antigens and proteins of the self. Kappler and Marrack both are Howard Hughes Medical Institute investigators at the National Jewish Center for Immunology and Respiratory Medicine in Denver and members of the National Academy of Sciences. Kappler, 51, and Marrack, 49, are partners in marriage as well as colleagues in the laboratory.

The prize, which included a $22,000 award shared by the two scientists, was presented by Columbia's president, George Rupp, on January 19 in New York. Established in 1967 to honor research in biology or biochemistry, the Horwitz Prize is seen as a strong predictor for the Nobel Prize--29 of 53 recipients later received the...

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