Interdisciplinary Research

These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.T.A. Allen et al., "The SINE-encoded mouse B2 RNA represses mRNA transcription in response to heat shock," Nat Struct Mol Biol, 11:816–21, September 2004.A small, noncoding RNA, called B2, is expressed during heat shock and represses transcription from RNA polymerase II. Interestingly, B2 RNA is transcribed from a DNA region previously thought to

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These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.

T.A. Allen et al., "The SINE-encoded mouse B2 RNA represses mRNA transcription in response to heat shock," Nat Struct Mol Biol, 11:816–21, September 2004.

A small, noncoding RNA, called B2, is expressed during heat shock and represses transcription from RNA polymerase II. Interestingly, B2 RNA is transcribed from a DNA region previously thought to be "junk DNA" within the mouse genome. (See also C.A. Espinoza et al., Nat Struct Mol Biol, 11:822–9, September 2004.)

- Samuel ButcherUniversity of Wisconsin, Madison

I. Splawski et al., "Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism," Cell, 119:19–31, Oct. 1, 2004.

This fascinating paper identifies the mutation in Timothy syndrome to be in the gene for the L-type calcium channel CaV1.2. The paper serves to underline the enormous importance of correct control ...

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