Editorial

Opinion

When Hypotheses Dominate
When Hypotheses Dominate
Scientific experimentation is based on examining falsifiable hypotheses, and not simply using relatively meaningless experiments to prop up thedogma du jour.

Letter

NIH Conflicts of Interest
NIH Conflicts of Interest
I do not know what all the fuss is about over conflicts of interest and the ethics of NIH scientists consulting with biotech companies.
On Downsizing the Status of Science
On Downsizing the Status of Science
There are two quite distinct contributors to the "disagreements over status of scientific evidence"

Notebook

The buzz about cheapdate
The buzz about cheapdate
Fly people have a notoriously off-putting way about naming genes.
Smallpox WHO?
Smallpox WHO?
Last month the World Health Organization's external committee on smallpox recommended that the two scientific teams possessing smallpox virus be allowed to insert a green fluorescent marker gene into the virus to test the efficacy of potential antismallpox drugs.
A new flavor of genomics
A new flavor of genomics
The European public's dislike for genetically modified foods shows no sign of waning, but Denmark's ingredient firms aren't letting a little thing like overwhelming public distrust stop them.

Feature

The Life Science Industry Awards
The Life Science Industry Awards
In terms of innovation, the life science industry has few peers.

Research

Brain Imaging Struggles for Psychiatric Respect
Brain Imaging Struggles for Psychiatric Respect
Psychiatrists can draw upon long clinical experience with adult patients to surmise why antidepressant medications foster suicidal thoughts and behavior in some children, as the US Food and Drug Administration warned this fall.
Sir2: Scrambling for Answers
Sir2: Scrambling for Answers
Low-calorie diets extend lifespan in almost every model tested, but scientists can't yet agree on what controls this phenomenon.

Hot Paper

Shocking Disparities in Voltage-Dependent Channels
Shocking Disparities in Voltage-Dependent Channels
The ion channel field has been a bit charged up lately, thanks largely to an impressive series of crystalline structures published by Rod MacKinnon's group at Rockefeller University.

Vision

Conversations in Genetics
Conversations in Genetics
As formal and methodological as it sometimes appears, science remains at its heart a process of storytelling.

Briefs

Triassic reptiles had live young
Triassic reptiles had live young
The largest and most diverse group of Triassic aquatic reptiles gave birth to live young, researchers recently reported.
Interdisciplinary Research
Interdisciplinary Research
These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.T.A. Allen et al., "The SINE-encoded mouse B2 RNA represses mRNA transcription in response to heat shock," Nat Struct Mol Biol, 11:816–21, September 2004.A small, noncoding RNA, called B2, is expressed during heat shock and represses transcription from RNA polymerase II. Interestingly, B2 RNA is transcribed from a DNA region previously thought to
Kicking the habit with RNAi
Kicking the habit with RNAi
RNA interference can turn off morphine production in poppies, according to a group from the Commonwealth Scientific and Industrial Research Organization (CSIRO) Plant Industry in Canberra, Australia.

Technology

Ten Technologies in Five Years
Ten Technologies in Five Years
When scientists make long-term research plans, they must try to anticipate how emerging technologies will influence their work in the coming years.
O Come, All Ye Scientists
O Come, All Ye Scientists
Scientists from Manhattan to Pasadena, Moscow to Johannesburg, responded to The Scientist's question, "What gift do you most want this holiday season, and why?" Answers included the practical (sliceable gel blocks), the whimsical (a Star Trek tricorder), and meteorological (another El Niño). But what they all had in common was the desire for that most intangible and elusive of gifts: hastened progress in the researchers' respective fields.TREKKIAN DELIGHTFor upcoming missions to Mars and Eu

Tools and Technology

Presents for Profs, 2004
Presents for Profs, 2004
Give your prof a dose of cheer this holiday season with this little USB-powered Christmas tree.
The Trouble with Membranes
The Trouble with Membranes
Membrane proteins comprise the majority of drug targets.
More Data, Less Damage
More Data, Less Damage
newly released confocal microscope, the Eclipse C1-Plus, sports a range of new features, including new adjustable lasers, according to Jeff Larson, Nikon's US product manager for confocal microscopes.
Squeezing Out More Gene-Expression Data
Squeezing Out More Gene-Expression Data
In the world of gene-expression profiling, microarrays reign, but they are not without drawbacks.

BioBusiness

Tapping a Stem Cell Goldmine
Tapping a Stem Cell Goldmine
Embryonic stem cell research is proceeding apace in many nations but continues to face political and economic hurdles in the United States, despite California voters' approval of a $3 billion war chest for stem cell research conducted in that state.
Choosing A Company Logo
Choosing A Company Logo
For big companies with a lot at stake, logo design and development is big business.

Update

Greenpeace in Germany Challenges a Stem Cell Patent
Greenpeace in Germany Challenges a Stem Cell Patent
The German arm of the environmental lobby group Greenpeace is disputing a patent on the grounds that it allows the commercial exploitation of human stem cells.
EU to Researchers: Have Grant Money, Can Travel
EU to Researchers: Have Grant Money, Can Travel
Research bodies in 10 European countries will allow scientists to take grant money with them when they move between their nations, according to a letter of intent announced in November by the German Research Foundation (DFG).

Atlas

Focus on Seattle
Focus on Seattle
As the largest city in the northwest United States, Seattle is probably known less for biotech than it is for aerospace (Boeing), software (Microsoft in nearby Redmond), coffee (Starbucks), and online retail (Amazon.com).

Reverse Transcript

Seeking Accurate Traffic Reports
Seeking Accurate Traffic Reports
On the desk in Jennifer Lippincott-Schwartz's office sits a small box labeled "Mr. Wizard's Golgi Model Kit."