These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.

N. Touret et al., "Quantitative and dynamic assessment of the contribution of the ER to phagosome formation," Cell, 123:157–170, Oct. 7, 2005.

Aligning an impressive array of methods, this study provides strong evidence against the recently proposed model of a significant contribution of endoplasmic reticulum (ER) membranes during early phagosome biogenesis. Quantitative approaches are used to demonstrate that ER membrane components are absent from phagosomes both in macrophages and dendritic cells, while an early and substantial contribution of endosomal membranes is readily detected.

Peter Van EndertNational Institute for Medical Research Safety (INSERM), France

D.T. Nair et al., "Rev1 employs a novel mechanism of DNA synthesis using a protein template,"Science, 309:2219–22, Sept. 30, 2005.

This article reports the fascinating finding that Rev1, a member of the translesion synthesis...

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