Lessons from Chimeras

The chimera marmoset story reported linkurl:here;http://www.the-scientist.com/news/home/53033/ and elsewhere is fascinating; I was stunned by the possibility, not heavily noted in a lot of press, that male cells might have made it into the germline of a female - that is XY cells from a male might have developed into eggs in his female twin sister resulting in a live birth. Germline transmission of one's brothers cells is interesting enough, but the idea of XY eggs is particularly interesting --

Written byBrendan Maher
| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share
The chimera marmoset story reported linkurl:here;http://www.the-scientist.com/news/home/53033/ and elsewhere is fascinating; I was stunned by the possibility, not heavily noted in a lot of press, that male cells might have made it into the germline of a female - that is XY cells from a male might have developed into eggs in his female twin sister resulting in a live birth. Germline transmission of one's brothers cells is interesting enough, but the idea of XY eggs is particularly interesting -- not just for the fact that a female had her brother's baby without all that messy incest. Another interesting chimera story, this one in humans, linkurl:was noted in the media;http://www.nature.com/news/2007/070326/full/070326-1.html;jsessionid=AE244B09CB3C69822F0B1B3B2DF74872 earlier this week. In a unique event researchers ascertained that a pair of twins, one phenotypically male and one hermaphroditic with ambiguous genitalia, were both actually XX/XY chimeras of each other. The twins developed, DNA analysis suggests, from a single egg fertilized by two sperm. linkurl:See the paper here.;http://www.springerlink.com/content/m5q6420770g60643/ And unlike in most observed human chimeras the mixed cells appear in several populations In addition to some of the philosophical quandaries such events raise about the definition of self from a genetic standpoint (Carl Zimmer did a nice job with this in the linkurl:__Times__;http://www.nytimes.com/2007/03/27/science/27marm.html?_r=1&oref=slogin Tuesday), both studies speak to crucial developmental strictures even if they are simply rare or unique cases. The marmosets suggest that it might not be so difficult for a male germ cell to develop into a functional egg exposing a bit more about natural linkurl:stem cell;http://www.the-scientist.com/news/home/53034/ plasticity, and the human story may shed light on the 'default' developmental program of sex, which has generally been assumed to be female (although that tide has been turning).
Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Meet the Author

Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina
Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

Abstract illustration of spheres with multiple layers, representing endoderm, ectoderm, and mesoderm derived organoids

Organoid Origins and How to Grow Them

Thermo Fisher Logo

Products

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo
Abstract background with red and blue laser lights

VANTAstar Flexible microplate reader with simplified workflows

BMG LABTECH