Molecular Biology

Date: January 6, 1992, pp.16 S.C. Hyde, P. Emsley, M.J. Hartshorn, M.M. Mimmack, et al., "Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance, and bacterial transport," Nature, 346:362-65, 1990. (MOLECULAR BIOLOGY) Christopher F. Higgins (Microbial Genetics Laboratory, Imperial Cancer Research Fund, University of Oxford, England): "The ATP- binding cassette superfamily of transporters includes many biologically and clinically important proteins, such


Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share


Date: January 6, 1992, pp.16

S.C. Hyde, P. Emsley, M.J. Hartshorn, M.M. Mimmack, et al., "Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance, and bacterial transport," Nature, 346:362-65, 1990. (MOLECULAR BIOLOGY) Christopher F. Higgins (Microbial Genetics Laboratory, Imperial Cancer Research Fund, University of Oxford, England):

"The ATP- binding cassette superfamily of transporters includes many biologically and clinically important proteins, such as the cystic fibrosis protein (CFTR), the human multidrug resistance protein (MDR), and the peptide transporter of the MHC complex.

"A highly conserved ATP-binding domain is diagnostic of this superfamily of proteins. We are therefore very interested in understanding the mechanisms by which this cassette couples the process of ATP hydrolysis to transport.

"Because the prospect of using crystallographic methods to determine the structure of the ATP-binding cassette is remote at present, we modeled the structure. This model provides a framework for designing experiments and for understanding ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here
3D illustration of a gold lipid nanoparticle with pink nucleic acid inside of it. Purple and teal spikes stick out from the lipid bilayer representing polyethylene glycol.
February 2025, Issue 1

A Nanoparticle Delivery System for Gene Therapy

A reimagined lipid vehicle for nucleic acids could overcome the limitations of current vectors.

View this Issue
Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

sartorius logo
Considerations for Cell-Based Assays in Immuno-Oncology Research

Considerations for Cell-Based Assays in Immuno-Oncology Research

Lonza
An illustration of animal and tree silhouettes.

From Water Bears to Grizzly Bears: Unusual Animal Models

Taconic Biosciences
Sex Differences in Neurological Research

Sex Differences in Neurological Research

bit.bio logo

Products

Photo of a researcher overseeing large scale production processes in a laboratory.

Scaling Lentiviral Vector Manufacturing for Optimal Productivity

Thermo Fisher Logo
Collage-style urban graphic of wastewater surveillance and treatment

Putting Pathogens to the Test with Wastewater Surveillance

An illustration of an mRNA molecule in front of a multicolored background.

Generating High-Quality mRNA for In Vivo Delivery with lipid nanoparticles

Thermo Fisher Logo
Tecan Logo

Tecan introduces Veya: bringing digital, scalable automation to labs worldwide