Molecular Biology

T. Furuichi, S. Yoshikawa, A. Miyawaki, K. Wada, N. Maeda, K. Mikoshiba, "Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400," Nature, 342, 32-8, 2 November 1989. Katsuhiko Mikoshiba (Institute for Protein Research, Osaka University, Japan): "Inositol trisphosphate (InsP3) is considered to be a second messenger for the release of calcium. We determined the structure of the InsP3 receptor by cDNA cloning. We also showed that the InsP3 receptor


Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

T. Furuichi, S. Yoshikawa, A. Miyawaki, K. Wada, N. Maeda, K. Mikoshiba, "Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400," Nature, 342, 32-8, 2 November 1989.

Katsuhiko Mikoshiba (Institute for Protein Research, Osaka University, Japan): "Inositol trisphosphate (InsP3) is considered to be a second messenger for the release of calcium. We determined the structure of the InsP3 receptor by cDNA cloning. We also showed that the InsP3 receptor itself has an InsP3 binding site and that it forms a calcium channel on the endoplasmic reticulum. We proved that the InsP3 receptor is a new type of calcium channel, different from the ligand-operated ion channels so far analyzed. The homology to InsP3 receptor was found only in the ryanodine receptor on the sarcoplasmic reticulum specifically developed in skeletal muscle. This paper opened a new field for the calcium regulation system by presenting a new type of calcium channel ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here
3D illustration of a gold lipid nanoparticle with pink nucleic acid inside of it. Purple and teal spikes stick out from the lipid bilayer representing polyethylene glycol.
February 2025, Issue 1

A Nanoparticle Delivery System for Gene Therapy

A reimagined lipid vehicle for nucleic acids could overcome the limitations of current vectors.

View this Issue
Considerations for Cell-Based Assays in Immuno-Oncology Research

Considerations for Cell-Based Assays in Immuno-Oncology Research

Lonza
An illustration of animal and tree silhouettes.

From Water Bears to Grizzly Bears: Unusual Animal Models

Taconic Biosciences
Sex Differences in Neurological Research

Sex Differences in Neurological Research

bit.bio logo
New Frontiers in Vaccine Development

New Frontiers in Vaccine Development

Sino

Products

Tecan Logo

Tecan introduces Veya: bringing digital, scalable automation to labs worldwide

Explore a Concise Guide to Optimizing Viral Transduction

A Visual Guide to Lentiviral Gene Delivery

Takara Bio
Inventia Life Science

Inventia Life Science Launches RASTRUM™ Allegro to Revolutionize High-Throughput 3D Cell Culture for Drug Discovery and Disease Research

An illustration of differently shaped viruses.

Detecting Novel Viruses Using a Comprehensive Enrichment Panel

Twist Bio