T. Furuichi, S. Yoshikawa, A. Miyawaki, K. Wada, N. Maeda, K. Mikoshiba, "Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400," Nature, 342, 32-8, 2 November 1989.
Katsuhiko Mikoshiba (Institute for Protein Research, Osaka University, Japan): "Inositol trisphosphate (InsP3) is considered to be a second messenger for the release of calcium. We determined the structure of the InsP3 receptor by cDNA cloning. We also showed that the InsP3 receptor itself has an InsP3 binding site and that it forms a calcium channel on the endoplasmic reticulum. We proved that the InsP3 receptor is a new type of calcium channel, different from the ligand-operated ion channels so far analyzed. The homology to InsP3 receptor was found only in the ryanodine receptor on the sarcoplasmic reticulum specifically developed in skeletal muscle. This paper opened a new field for the calcium regulation system by presenting a new type of calcium channel ...
