J.H. Brown, T.S. Jardetzky, J.C. Gorga, L.J. Stern, R.G. Urban, J.L. Strominger, D.C. Wiley, "Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1," Nature, 364:33-9, 1993. (Cited in 235 publications through December 1994)

Comments by Jerry H. Brown

This paper is the first description of the three-dimensional structure of a class II human leukocyte antigen (HLA). Also known as histocompatibility antigens, the HLA molecules are present on various cell surfaces to help lymphocytes of the immune system recognize and respond to their targets. The structural description of such molecules, explain the authors and other researchers, provides a basis for understanding the molecular mechanisms of such processes as immune recognition.

As far back as 1987, this group of scientists published the first crystal structures of class I HLA molecules (P.J. Bjorkman et al., Nature, 329:506-12, 1987; P.J. Bjorkman et al., Nature, 329:512-8, 1987). But the structure of...

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