Neurotoxin Concerns, Controversy Escalate

Scientists are realizing that substances in the environment can have devastating effects on the human nervous system For decades, neuropathologist John Olney waged a one-man crusade to have "excitotoxins," chemicals in the brain that cause nerve cells to self-destruct, removed from foods. One of the worst, he argued, was glutamate, consumed by millions as the food flavoring monosodium glutamate. But nobody really paid much mind to Olney's concerns. The Food and Drug Administration (FDA) did no

| 10 min read

Register for free to listen to this article
Listen with Speechify
0:00
10:00
Share


Scientists are realizing that substances in the environment can have devastating effects on the human nervous system
For decades, neuropathologist John Olney waged a one-man crusade to have "excitotoxins," chemicals in the brain that cause nerve cells to self-destruct, removed from foods. One of the worst, he argued, was glutamate, consumed by millions as the food flavoring monosodium glutamate. But nobody really paid much mind to Olney's concerns. The Food and Drug Administration (FDA) did not agree, and in 1970 judged the additive safe. So did, in that same year, a committee from the National Academy of Sciences (NAS).

But by 1980 scientists were beginning to realize that there were substances that warranted their attention. Lead in paint impaired learning. Epidemiological data revealed that Lucel-7, a substance used in making bathtubs, caused neurological damage in workers. In 1983, about 500 drug-users in San Francisco developed what appeared to be Parkinson's ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

  • Elizabeth Pennisi

    This person does not yet have a bio.

Published In

Share
3D illustration of a gold lipid nanoparticle with pink nucleic acid inside of it. Purple and teal spikes stick out from the lipid bilayer representing polyethylene glycol.
February 2025, Issue 1

A Nanoparticle Delivery System for Gene Therapy

A reimagined lipid vehicle for nucleic acids could overcome the limitations of current vectors.

View this Issue
Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

sartorius logo
Considerations for Cell-Based Assays in Immuno-Oncology Research

Considerations for Cell-Based Assays in Immuno-Oncology Research

Lonza
An illustration of animal and tree silhouettes.

From Water Bears to Grizzly Bears: Unusual Animal Models

Taconic Biosciences
Sex Differences in Neurological Research

Sex Differences in Neurological Research

bit.bio logo

Products

Photo of a researcher overseeing large scale production processes in a laboratory.

Scaling Lentiviral Vector Manufacturing for Optimal Productivity

Thermo Fisher Logo
Discover a serum-free way to produce dendritic cells and macrophages for cell therapy applications.

Optimizing In Vitro Production of Monocyte-Derived Dendritic Cells and Macrophages

Thermo Fisher Logo
Collage-style urban graphic of wastewater surveillance and treatment

Putting Pathogens to the Test with Wastewater Surveillance

An illustration of an mRNA molecule in front of a multicolored background.

Generating High-Quality mRNA for In Vivo Delivery with Lipid Nanoparticles

Thermo Fisher Logo