Directed Evolution, Phage Display Nab Chemistry Nobel

The 2018 award goes to Frances Arnold, Gregory Winter, and George Smith.

Written byKerry Grens and Catherine Offord
| 4 min read

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Caltech’s Frances Arnold, who advanced a technique called directed evolution to shape the function of enzymes, has received the Nobel Prize in Chemistry today (October 3). She shares the honor with George Smith, now emeritus professor of the University of Missouri, and Gregory Winter, emeritus group leader at the Medical Research Council Laboratory of Molecular Biology (LMB) in Cambridge, UK. Smith and Winter are both recognized for their work on a lab technique known as phage display in the directed evolution of new proteins—in particular, for the production of antibody therapeutics.

“I’d like to congratulate this year’s laureates for their tremendous breakthrough work in using chemistry to speed nature's own processes,” Peter Dourhout, president of the American Chemical Society, says in a statement. “The breakthroughs from these researchers enable that to occur thousands of times faster than nature to improve medicines, fuels and other products. This is truly directed evolution ...

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  • kerry grens

    Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at WHYY in Philadelphia, and the health and science reporter at New Hampshire Public Radio. Kerry got her start in journalism as a AAAS Mass Media fellow at KUNC in Colorado. She has a master’s in biological sciences from Stanford University and a biology degree from Loyola University Chicago.

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  • After undergraduate research with spiders at the University of Oxford and graduate research with ants at Princeton University, Catherine left arthropods and academia to become a science journalist. She has worked in various guises at The Scientist since 2016. As Senior Editor, she wrote articles for the online and print publications, and edited the magazine’s Notebook, Careers, and Bio Business sections. She reports on subjects ranging from cellular and molecular biology to research misconduct and science policy. Find more of her work at her website.

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