Researchers Transplant Human Neurons into Rat Brains

The human cells, engineered to respond to blue light, influenced rat behavior when stimulated.

Written byKatherine Irving
| 2 min read
a section of a rat brain is imaged in dull green. a much brighter green human organoid takes up a large portion of the left side of the brain.
Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

For the first time, researchers have successfully transplanted human neurons into the brains of baby rats, they report today (October 12) in Nature. The human cells formed connections with rat neurons and could be used to control the rats’ behavior.

“It’s a very important . . . very cool study,” Yun Li, a molecular geneticist at the University of Toronto who was not involved in the research, tells MIT Technology Review. “The fact that they succeeded in many of these experiments is quite extraordinary.”

To perform human cell experiments, especially when studying the effects of certain drugs, scientists have developed models called organoids: tiny structures grown from stem cells that mimic the human brain or other organs. However, they can’t replicate the complexity of real human neuron development on their own, Science News reports.

In a bid to further organoid development, scientists transplanted human cerebral organoids into the brains of ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • A black and white headshot of Katherine Irving

    Katherine Irving is an intern at The Scientist. She studied creative writing, biology, and geology at Macalester College, where she honed her skills in journalism and podcast production and conducted research on dinosaur bones in Montana. Her work has previously been featured in Science.  

    View Full Profile
Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Refeyn logo

Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies

Parse Logo

Parse Biosciences and Graph Therapeutics Partner to Build Large Functional Immune Perturbation Atlas

Sino Biological Logo

Sino Biological's Launch of SwiftFluo® TR-FRET Kits Pioneers a New Era in High-Throughout Kinase Inhibitor Screening

SPT Labtech Logo

SPT Labtech enables automated Twist Bioscience NGS library preparation workflows on SPT's firefly platform