NIH AIDS vaccine trial nixed

The National Institute of Allergy and Infectious Disease (NIAID) announced today (July 17) that it will not conduct a trial of an HIV vaccine that its own Vaccine Research Center (VRC) developed. It was known as the PAVE 100 trial. "Based on the available scientific information, NIAID has decided that the VRC vaccine regimen did not warrant a trial of this size and scope and that PAVE 100 will not proceed," the NIAID said in a linkurl:press release;http://www3.niaid.nih.gov/news/newsreleases/20

| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share
The National Institute of Allergy and Infectious Disease (NIAID) announced today (July 17) that it will not conduct a trial of an HIV vaccine that its own Vaccine Research Center (VRC) developed. It was known as the PAVE 100 trial. "Based on the available scientific information, NIAID has decided that the VRC vaccine regimen did not warrant a trial of this size and scope and that PAVE 100 will not proceed," the NIAID said in a linkurl:press release;http://www3.niaid.nih.gov/news/newsreleases/2008/pave100.htm. The trial, which was to be carried out by the linkurl:Partnership for AIDS Vaccine Evaluation;http://www.hivpave.org/ (PAVE) and sponsored by NIAID, involved administering a recombinant vaccine based on adenovirus type 5 (Ad5) to 2,400 US men who have sex with other men. The PAVE 100 vaccine was similar to a Merck vaccine involved in a failed trial that was linkurl:halted;http://www.the-scientist.com/blog/display/53633/ last year, except that researchers planned to give a single dose of the Ad5 vaccine after three DNA-based immunizations designed to stimulate the immune system, while the Merck vaccine was administered in three injections with no prior DNA-based priming. Though the NIH's AIDS Vaccine Research Subcommittee linkurl:recommended;http://www.the-scientist.com/blog/display/54724/ last month going ahead with the PAVE 100 trial, the NIAID decided not to proceed, saying that the vaccine is "scientifically intriguing and sufficiently different from previously tested HIV vaccines to consider testing it in a smaller, more focused clinical study." The agency said that it would "entertain a proposal for an alternative study with one specific goal: to determine if the vaccine regimen significantly lowers viral load -- the amount of HIV in the blood of vaccinated individuals who may later become infected with HIV."
Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Meet the Author

  • Bob Grant

    From 2017 to 2022, Bob Grant was Editor in Chief of The Scientist, where he started in 2007 as a Staff Writer.
Share
TS Digest January 2025
January 2025, Issue 1

Why Do Some People Get Drunk Faster Than Others?

Genetics and tolerance shake up how alcohol affects each person, creating a unique cocktail of experiences.

View this Issue
Sex Differences in Neurological Research

Sex Differences in Neurological Research

bit.bio logo
New Frontiers in Vaccine Development

New Frontiers in Vaccine Development

Sino
New Approaches for Decoding Cancer at the Single-Cell Level

New Approaches for Decoding Cancer at the Single-Cell Level

Biotium logo
Learn How 3D Cell Cultures Advance Tissue Regeneration

Organoids as a Tool for Tissue Regeneration Research 

Acro 

Products

Artificial Inc. Logo

Artificial Inc. proof-of-concept data demonstrates platform capabilities with NVIDIA’s BioNeMo

Sapient Logo

Sapient Partners with Alamar Biosciences to Extend Targeted Proteomics Services Using NULISA™ Assays for Cytokines, Chemokines, and Inflammatory Mediators

Bio-Rad Logo

Bio-Rad Extends Range of Vericheck ddPCR Empty-Full Capsid Kits to Optimize AAV Vector Characterization

Scientist holding a blood sample tube labeled Mycoplasma test in front of many other tubes containing patient samples

Accelerating Mycoplasma Testing for Targeted Therapy Development