Viruses have long been recognized as useful vehicles for delivering genetic information into cells, from the earliest days of molecular genetics and pioneering work of Hershey and Chase on transducing bacteriophages. And since the development of techniques for disabling the virus-production machinery, viral vectors have been used extensively for cloning and expressing genes in both prokaryotic and eukaryotic systems. Adenovirus is one of a handful of eukaryotic viruses in use today--the only nonretrovirus--and while perhaps in today's environment it is thought more of as a gene delivery system, this virus has a number of features that make it useful for overproducing eukaryotic proteins as well: the ability to produce correctly modified and biologically active proteins, a large host range, the ability to infect both dividing and nondividing cells (unlike retroviruses), and the ability to replicate to a high titer.
 Quantum Biotechnologies' AdenoQuest Transfer Vector Map |
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