Null or Nil

Null or Nil Steve Bunk's 5-PRIME on the null hypothesis was a good, brief piece.1 However, he made the common error of confusing the null hypothesis (the hypothesis against which the research result is tested) with the nil hypothesis (definition: if samples come from populations with identical parameters, the hypothesized difference is zero). The null hypothesis--that is, the one "sought to be nullified"--may be nil. But it also may be a population parameter, or a specified difference betwe

| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share

Steve Bunk's 5-PRIME on the null hypothesis was a good, brief piece.1 However, he made the common error of confusing the null hypothesis (the hypothesis against which the research result is tested) with the nil hypothesis (definition: if samples come from populations with identical parameters, the hypothesized difference is zero). The null hypothesis--that is, the one "sought to be nullified"--may be nil. But it also may be a population parameter, or a specified difference between population parameters, against which any difference between the samples are to be tested.

Statistical significance is a function of sample size. With large enough samples, practically every difference will be statistically significant; with small samples, important results may be overlooked if statistical significance is relied on exclusively. Bunk's reminder that statistical significance does not necessarily indicate substantive significance is, for a few reasons, on target.

James P. Shaver
Hyrum, UT
shaver@cc.usu.edu

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here
December digest cover image of a wooden sculpture comprised of multiple wooden neurons that form a seahorse.
December 2025, Issue 1

Wooden Neurons: An Artistic Vision of the Brain

A neurobiologist, who loves the morphology of cells, turns these shapes into works of art made from wood.

View this Issue
Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

Merck
Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

MilliporeSigma purple logo
Abstract wireframe sphere with colorful dots and connecting lines representing the complex cellular and molecular interactions within the tumor microenvironment.

Exploring the Inflammatory Tumor Microenvironment 

Cellecta logo
An image of a DNA sequencing spectrum with a radial blur filter applied.

A Comprehensive Guide to Next-Generation Sequencing

Integra Logo

Products

brandtech logo

BRANDTECH® Scientific Announces Strategic Partnership with Copia Scientific to Strengthen Sales and Service of the BRAND® Liquid Handling Station (LHS) 

Top Innovations 2026 Contest Image

Enter Our 2026 Top Innovations Contest

Biotium Logo

Biotium Expands Tyramide Signal Amplification Portfolio with Brighter and More Stable Dyes for Enhanced Spatial Imaging

Labvantage Logo

LabVantage Solutions Awarded $22.3 Million U.S Customs and Border Protection Contract to Deliver Next-Generation Forensic LIMS