Physiology

Edited by: Neeraja Sankaran
A.S. Weyrich, X.L. Ma, D.J. Lefer, K.H. Albertine, A.M. Lefer, "In vivo neutralization of P-selectinprotects feline heart andendothelium in myocardialischemia and reperfusion injury," Journal of Clinical Investigation, 91:2620-29, 1993. (Cited in 53publications through February 1995)

Comments by Allan M. Lefer,Thomas Jefferson University

GAINS ON THE HEART FRONT: Allan Lefer's team has shown that neutralizing the glycoprotein P-selectin can confer protection against injury to the heart cells and hence, heart attacks in cats.

Using an animal model for heart attack, Allan Lefer's team of researchers at Thomas Jefferson University have reported success in protecting the heart muscle cells from damage by neutralizing a group of glycoproteins called selectins.

Normally present in platelets, leukocytes, and endothelial cells, the selectins play a role in cellular communication and movement. Lefer, chairman of the physiology department at Jefferson and a professor in the department, explains that these glycoproteins...